Increased expression of IL-37 correlates with TNF-? levels and disease stage in endometriosis patients

Abstract Background IL-37 is an anti-inflammatory cytokine that increases in several inflammatory diseases with the main inducing signal for its production being pro-inflammatory cytokines like TNF-?. We aimed to assess correlation between peritoneal fluid levels of and TNF-? endometriosis patients investigate their association disease stage. Levels were assessed 50 23 endometriosis-free females using enzyme-linked immunosorbent assay. also serum assay expression mRNA cells polymerase chain reaction. Results Peritoneal higher than control females. Also, late early endometriosis. In addition, IL-37, as well cells, controls. patients, positively correlated Conclusion Collectively, our results show increased correlate TNF-?, one signals production.